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研究揭示皮肤癌的脑转移机制

2024-07-07 18:46:07 浏览:73

新华社耶路撒冷9月25日电（记者王卓伦 吕迎旭）以色列等国研究人员日前在美国《临床检查杂志·观察》上发表论文说，他们发现了黑色素瘤这种皮肤癌转移到大脑的机制，并相应找到了抑制癌转移的方法。

据介绍，约90%的黑色素瘤患者会在晚期发生脑转移。但大脑是一个受较好保护的器官，血脑屏障通常可以阻止有害物质进入大脑。医学界一直在探索皮肤癌脑转移的原因。

以色列特拉维夫大学等机构的研究人员使用来自皮肤、血液和脑的组织以及相关癌细胞，在实验室中模拟了它们在人体内的相互作用。结果发现，黑色素瘤这种皮肤癌细胞进入血液后会释放出名为CCR2和CCR4的蛋白质，而大脑中的星形胶质细胞会分泌一种名为MCP-1的蛋白质，它们之间的相互作用会导致癌细胞进入大脑。

研究人员发现用两种方法可以抑制癌细胞脑转移：一是利用抗体和小分子药物阻断蛋白质MCP-1发挥作用，二是用基因编辑技术敲除癌细胞中与蛋白质CCR2和CCR4相关的基因。实验室研究显示，这两种方法均可抑制癌细胞的脑转移，根据干预阶段的不同，可将肿瘤生长抑制60%至80%。

上述抑制皮肤癌脑转移的方法尚未经过临床试验，但研究人员表示，其中使用的抗体和小分子药物已经在治疗其他疾病的临床试验中通过了安全性测试，因此有望在此基础上较快开发出可临床应用的疗法。（完）

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